Abstract:
Multiple sclerosis (MS) is an immune-related demyelinating disease of the central nervous system. The onset age of MS is usually between 20-40 years, showing a heterogeneous clinical feature. Due to the high disability rate, MS causes a huge burden to the society. MS is a complex disease caused by the genetic and environmental factors, in which genetic factors play a critical role. HLA gene complex is the most important determinant in MS risk, with a risk factor rate more than 60%. HLA gene complex has been a focus in MS research worldwide.
Key words:
Multiple sclerosis,
HLA antigens,
Genetics,
Review
摘要: 多发性硬化为一种免疫相关性中枢神经系统脱髓鞘疾病,临床表现呈异质性,好发于青壮年女性,病残率高,给患者家庭及社会造成沉重负担。遗传因素和环境因素共同参与其发病机制,而HLA 基因复合体为重要的遗传学决定因素,占易感风险的60%,对其研究是目前多发性硬化遗传学研究的热点和难点。
关键词:
多发性硬化,
HLA 抗原,
遗传学,
综述
QIU Wei, HU Xue-qiang. Human leukocyte antigen susceptibility genes in multiple sclerosis[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2012, 12(2): 127-130.
邱伟,胡学强. 多发性硬化人类白细胞抗原易感基因研究进展[J]. 中国现代神经疾病杂志, 2012, 12(2): 127-130.