Abstract: Objective To clarify the intrinsic risk factors contributing to postoperative infection in patients with recurrent brain tumor. Methods The clinical characteristics of patients with recurrent intracranial neoplasm were collected and analysed retrospectively. The intrinsic risk factors for postoperative intracranial infection were evaluated by χ2 test. The multivariate Logistic regression analysis was employed to select the independent variables associated with postoperative intracranial infection. Results Tumor size, long-term bed, preoperative extracranial infection, diabetes, malnutrition, anemia, hypoproteinemia, organ dysfunction and autoimmune disease had significant effect on postoperative infection, which revealed by the univariate analysis. Multivariate analysis showed that tumor size, preoperative extracranial infection and diabetes contributed to postoperative intracranial infection as independent risk factors. Conclusion Tumor size (diameter > 5 cm), preoperative extracranial infection and diabetes are potential predictors of high risk for postoperative intracranial infection. Efforts should be made to control the factors mentioned above in order to minimize the probability of postoperative infection in patients with recurrent intracranial neoplasm.

Key words: Neoplasm recurrence, local, Neoplasm metastasis, Postoperative complications, Central nervous system bacterial infections, Risk factors

摘要： 目的 分析复发性颅内肿瘤术后颅内感染的内在危险因素。方法 回顾分析复发性颅内肿瘤患者的临床特征，采用χ2 检验进行单因素分析筛选危险因素，多因素Logistic 逐步回归分析确定术后颅内感染的独立危险因素。结果 经单因素分析显示，肿瘤大小，长期卧床，术前合并颅外感染灶、糖尿病、营养不良、贫血、低蛋白血症、器官功能障碍、自身免疫性疾病等对复发性颅内肿瘤术后颅内感染有一定影响。多因素Logistic 逐步回归分析，肿瘤大小，术前合并颅外感染灶、糖尿病为术后颅内感染的独立危险因素。结论 对于复发性颅内肿瘤患者，肿瘤直径> 5 cm、术前合并颅外感染灶和糖尿病的患者术后发生颅内感染的风险较高，应加强对上述危险因素的控制，以降低术后颅内感染的风险。

关键词: 肿瘤复发, 局部, 肿瘤转移, 手术后并发症, 中枢神经系统细菌感染, 危险因素