Abstract: Objective To evaluate the effect of quality of life (QOL) in the refractoriness young epileptic patients of partial seizures with the neotype antiepileptic drugs (AEDs) of levetiracetam. Methods All the patients were randomly divided into 2 groups, one was the treatment-group with the drug of levetiracetam, another was the control-group with the placebo to therapy. The effective power was compared after completed the 12 weeks therapy and evaluated the life quality of 2 groups with Quality of Life in Epilepsy Inventory-31 (QOLIE-31), respectively. Sequentially, all the patients were switched to the openness-therapy with 500 mg levetiracetam per day for 12 weeks, the life quality of all the patients were also estimated by the same QOLIE-31 on the end of the therapy. Results The therapeutic effective power was obviously increased in the treatment-group (43.75% vs 35.72%, P = 0.031). The quality of life was significantly improved on the first end of 12 weeks treatment period with the treatment of levetiracetam (t = 3.905, P = 0.001), but the control-group did not increase their quality of life (t = 1.217, P = 0.245). The quality of life of patients in the 2 groups were significantly improved on the end of the 12 weeks for openness-therapy (t = 4.940, P=0.021; t = 2.575, P = 0.023). Conclusion Levetiracetam can treat the refractoriness young epileptic patients of partial seizures as an adjunctive treatment drug, it may significantly decrease the seizure frequency and it has advantage in improving the life quality of epileptic patients.

Key words: Piracetam, Epilepsies, partial, Drug therapy, Quality of life, Adolescent

摘要： 目的   评价新型抗癫痫药物左乙拉西坦添加治疗青年难治性部分性癫痫患者的疗效，以及对患者生活质量的影响。方法   30 例诊断明确的部分性发作青年患者随机分为左乙拉西坦组和吡拉西坦组，计算左乙拉西坦治疗第12 周末时治疗有效率；依据癫痫生活质量量表-31 分别评价两组患者在左乙拉西坦剂量维持期（12 周）和开放性治疗期（12 周）的生活质量。结果   治疗第12 周末时，左乙拉西坦组治疗有效率（43.75%，7/16）高于吡拉西坦组（35.72%，5/14；Fisher 精确概率法：P =0.031），生活质量明显改善（与基线比较：t = 3.905，P = 0.001）。治疗第24 周末时，两组患者生活质量较治疗前均显著改善（左乙拉西坦组：t = 4.940，P = 0.021；吡拉西坦组：t = 2.575，P = 0.023）。结论   左乙拉西坦作为抗癫痫药的添加治疗药物，能够显著减少青年难治性部分性癫痫患者的发作频率，快速有效地提高患者生活质量。

关键词: 吡拉西坦, 癫痫, 部分性, 药物疗法, 生活质量, 青少年