中国现代神经疾病杂志 ›› 2022, Vol. 22 ›› Issue (11): 973-980. doi: 10.3969/j.issn.1672-6731.2022.11.009

• 技术与方法 • 上一篇    下一篇

2 介入材料电反应性能和电凝血栓形成实验研究

吴涛, 吴垚, 陈爱林, 戴纯刚, 朱卿   

  1. 215004 苏州大学附属第二医院神经外科
  • 收稿日期:2022-10-31 出版日期:2022-11-25 发布日期:2022-12-09
  • 通讯作者: 朱卿,Email:suzhouneurosurgeon@126.com
  • 基金资助:
    江苏省研究生科研与实践创新计划(项目编号:SJCX20_1071);江苏省苏州市科技计划项目(项目编号:SYS2019067);江苏省苏州市科技计划项目(项目编号:SKJYD2021088);江苏省苏州市高新区医疗卫生科技计划项目(项目编号:2018Z014)

Experimental study on electroreactivity and electrocoagulation of interventional materials

WU Tao, WU Yao, CHEN Ai-lin, DAI Chun-gang, ZHU Qing   

  1. Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China
  • Received:2022-10-31 Online:2022-11-25 Published:2022-12-09
  • Supported by:
    This study was supported by Postgraduate Research and Practice Innovation Program of Jiangsu (No.SJCX20_1071), Suzhou Science and Technology Planning Project in Jiangsu (No.SYS2019067, SKJYD2021088), and Medical and Health Science and Technology Project of Suzhou High Tech Zone in Jiangsu (No.2018Z014).

摘要: 目的 探讨常用血管内介入材料电反应性能及其电凝血栓形成效果的差异。方法 采用万用表测量不同型号的常用微导丝和弹簧圈电阻值,获取反映介入材料电反应性能的物理参数。分别以生理盐水和新西兰白兔离体动脉血作为电解质进行体外电解产气实验,获取单位时间产气量,并通过扫描电子显微镜观察介入材料表面血栓附着情况。结果 电阻值测量显示,ASAHI、SilverSpeed、Traxcess微导丝和Axium弹簧圈导电性能良好,通电后均可发生电解产气现象,且电压与产气速度呈正相关关系(均P<0.05)。离体动脉血电凝结果显示,提高电压可获得更好的血栓形成质量。结论 电阻值测量可以初步筛选出适用于动脉内电凝的微导丝和弹簧圈,而电压是决定介入材料电解反应强度和血栓形成质量的关键因素。

关键词: 动脉瘤, 电解, 电凝术, 血栓形成, 模型,动物

Abstract: Objective To investigate the difference of electroreactivity and electrocoagulation of commonly used interventional materials.Methods The resistance of different types of micro-guide wire and spring coil are measured with a multimeter to obtain the physical parameters reflecting the conductivity. The in vitro electrolytic gas production experiment was carried out with physiological saline and isolated arterial blood of New Zealand white rabbits as the medium, the gas production data were obtained, and the thrombus adhesion on the surface of the materials was observed by scanning electron microscopy.Results The resistance measurement results showed ASAHI, SilverSpeed, Traxcess micro-guide wire and Axium spring coil have good conductivity, the electrolytic gas production could occur after power-up, and the voltage was positively correlated with gas production speed (P<0.05, for all). The results of in vitro arterial blood electrocoagulation showed that better thrombosis quality could be obtained by increasing the voltage.Conclusions The micro-guide wire and spring coil used for intra-arterial electrocoagulation can preliminarily selected by resistance measurement, and the voltage is the key factor to determine the electrical reaction intensity and thrombosis quality.

Key words: Aneurysm, Electrolysis, Electrocoagulation, Thrombosis, Models, animal