正常人脑磁图睡眠期枕区一过性正相尖波特点：同步脑磁图与脑电图对比分析

doi:10.3969/j.issn.1672-6731.2022.07.003

中国现代神经疾病杂志 ›› 2022, Vol. 22 ›› Issue (7): 555-563. doi: 10.3969/j.issn.1672-6731.2022.07.003

2 正常人脑磁图睡眠期枕区一过性正相尖波特点：同步脑磁图与脑电图对比分析

任洁钏¹, 杨春兰², 任国平¹, 杨春清¹, 乔慧³, 王群^1,4,5

1 100070 首都医科大学附属北京天坛医院神经病学中心;
2 100124 北京工业大学环境与生命学部;
3 100070 北京市神经外科研究所;
4 100070 北京, 国家神经系统疾病临床医学研究中心;
5 100069 北京脑重大疾病研究院

收稿日期:2022-07-08 出版日期:2022-07-25 发布日期:2022-08-01
基金资助:
国家自然科学基金青年科学基金资助项目（项目编号：81601126）；国家自然科学基金青年科学基金资助项目（项目编号：81801280）；北京市自然科学基金重点资助项目（项目编号：Z200024）；首都卫生发展科研专项（项目编号：首发2016-1-2011）；首都卫生发展科研专项（项目编号：首发2020-1-2013）

Characteristics of MEG positive occipital sharp transients of sleep in normal people: a simultaneous MEG-EEG study

REN Jie-chuan¹, YANG Chun-lan², REN Guo-ping¹, YANG Chun-qing¹, QIAO Hui³, WANG Qun^1,4,5

1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;
2 Department of Environment and Biology, Beijing University of Technology, Beijing 100124, China;
3 Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China;
4 China National Clinical Research Center for Neurological Diseases, Beijing 100070, China;
5 Beijing Institute for Brain Disorders, Beijing 100069, China

Received:2022-07-08 Online:2022-07-25 Published:2022-08-01
Contact: 王群,Email:wangq@ccmu.edu.cn
Supported by:
This study was supported by the National Natural Science Foundation of China for Young Scientists (No. 81601126, 81801280), Key Project of Beijing Natural Science Foundation (No. Z200024), and Capital Health Research and Development Project (No. 2016-1-2011, 2020-1-2013).

摘要/Abstract

摘要： 目的初步探讨健康成人睡眠期枕区一过性正相尖波（POSTS）脑磁图与脑电图的对应关系，并总结脑磁图POSTS波形和分布特点。方法同步采集2020年12月至2021年8月首都医科大学附属北京天坛医院招募的5例健康受试者睡眠期脑磁图与脑电图数据，分析脑磁图POSTS波形特点及其与脑电图POSTS的对应关系，采用单一等效电流偶极子方法对脑磁图POSTS进行溯源分析。结果共5例受试者共记录到睡眠期脑电图POSTS波形564个，剔除与心电图重合的POSTS波形后，同步出现的脑磁图对应枕区POSTS波形359个，脑磁图POSTS检出率为73.42%（359/489）。脑磁图POSTS波形变异性较大，POSTS偶极子主要分布于双侧枕叶中线区，包括距状沟、舌回、楔叶等，部分分布于距中线较远的枕颞内侧回、枕颞外侧回、枕皮质外侧等，少数分布于顶枕沟和楔前叶。结论脑磁图POSTS具有不同于脑电图POSTS的特点，临床判读时应注意识别，以更好地辨别生理性与病理性波形，为术前评估提供准确参考。

关键词: 睡眠期枕区一过性正相尖波(非MeSH词), 脑磁图描记术, 脑电描记术, 成年人

Abstract: Objective To preliminarily explore the correlation of positive occipital sharp transients of sleep (POSTS) in MEG and EEG, and summarize the characteristics of MEG POSTS morphology and localization. Methods The MEG and EEG signals were simultaneously recorded in 5 healthy subjects during sleep, who were recruited from December 2020 to August 2021 in Beijing Tiantan Hospital, Capital Medical University. The features of MEG POSTS and its relationship with EEG POSTS were summarized. Single equivalent current dipole (ECD) model was used to conduct source imaging for POSTS. Results About 564 EEG POSTS during sleep were recorded in 5 subjects. There were 359 simultaneous MEG POSTS in occipital region after exclusion of the POSTS overlapping with heart beat in ECG. The appearance rate of MEG POSTS was 73.42% (359/489). The MEG POSTS showed great variability in morphology. MEG POSTS dipoles were located mainly in bilateral midline regions of occipital lobe, including calcarine sulcus, lingual gyrus and cuneus; some in other parts of occipital lobe away from midline regions, such as medial occipitotemporal gyrus, lateral occipitotemporal gyrus and lateral occipital cortices; and a small portion in bilateral parietooccipital sulcus and precuneus. Conclusions MEG POSTS has characteristics different from EEG POSTS, so it is important to recognize POSTS correctly in clinical MEG reading to discriminate between physiological and pathological waves and provide precise information for presurgical evaluation of epilepsy.

Key words: Positive occipital sharp transients of sleep (not in MeSH), Magnetoencephalography, Electroencephalography, Adult

任洁钏, 杨春兰, 任国平, 杨春清, 乔慧, 王群. 正常人脑磁图睡眠期枕区一过性正相尖波特点：同步脑磁图与脑电图对比分析[J]. 中国现代神经疾病杂志, 2022, 22(7): 555-563.

REN Jie-chuan, YANG Chun-lan, REN Guo-ping, YANG Chun-qing, QIAO Hui, WANG Qun. Characteristics of MEG positive occipital sharp transients of sleep in normal people: a simultaneous MEG-EEG study[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2022, 22(7): 555-563.

http://journal11.magtechjournal.com/cjcnn/CN/Y2022/V22/I7/555

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