摘要：

目的 探讨不同类型静坐不能的临床表现、可能发病机制和治疗方法。方法与结果 共3 例静坐不能患者，例1 诊断为急性静坐不能、药源性帕金森综合征、缺铁性贫血，停用奥氮平，予普萘洛尔、阿普唑仑、苯海索和补铁治疗后好转；例2 诊断为迟发性静坐不能、迟发性运动障碍，逐渐减停利培酮、加用阿普唑仑后好转；例3 诊断为帕金森病静坐不能，继续予抗帕金森病药多巴丝肼、司来吉兰、普拉克索，加用阿普唑仑、普萘洛尔后好转。结论 不同类型静坐不能的治疗方法各异，临床应根据不同类型进行针对性治疗。

关键词: 精神运动性激动, 抗精神病药

Abstract:

Objective  To explore the clinical presentations, probable pathogenesis and therapy of different types of akathisia. Methods and Results There were 3 cases of akathisia in this report. The diagnosis of Case 1 was acute akathisia, drug-induced parkinsonism, and iron-deficiency anemia, and the symptoms were relieved after the patient stopped taking olanzapine and was treated with propranolol, alprazolam, benzhexol and iron supplementation. The diagnosis of Case 2 was tardive akathisia and tardive dyskinesia. After risperidone was gradually reduced and alprazolam was added, the symptoms were improved. The diagnosis of Case 3 was akathisia in Parkinson's disease (PD). After alprazolam and propranolol were added, while anti-PD drugs (levodopa and benserazide, selegiline and pramipexole) continued to be applied, the symptoms were alleviated. Conclusions When akathisia is treated, its type should be distinguished firstly, and then the treatment should be given according to different types.

Key words: Psychomotor agitation, Antipsychotic agents