摘要： 共60 例急性缺血性卒中患者，分别接受丁苯酞氯化钠注射液联合尿激酶治疗（30 例）或单纯尿激酶溶栓治疗（30 例），于治疗第1、5、15、30 和90 天时采用美国国立卫生研究院卒中量表和Barthel指数评价神经功能改善程度和疗效，同时观察药物不良反应。结果显示，治疗后两组患者各观察时间点神经功能均不同程度提高（P = 0.020）。联合治疗组患者治疗显效率为36.67％（11/30）、总有效率为93.33％（28/30），对照组显效率为10％（3/30）、总有效率为56.67%（17/30），组间差异有统计学意义（χ² =13.195，P = 0.004）；两组患者药物不良反应发生率差异无统计学意义（P = 0.572）。提示丁苯酞氯化钠注射液联合尿激酶治疗急性缺血性卒中疗效更佳。

关键词: 卒中, 苯丙酮类, 尿纤溶酶原激活物

Abstract: This paper aims to observe the therapeutic effect of butylphthalide sodium chloride injection combined with urokinase in the treatment of acute ischemic stroke. A total of 60 patients with acute ischemic stroke were randomly divided into 2 groups: combined treatment group (butylphthalide sodium chloride injection + urokinase, N = 30) and control group (urokinase only, N = 30). National Institute of Health Stroke Scale (NIHSS) and Barthel Index (BI) were used to evaluate the improvement of neurological function and curative effect. Adverse reactions were also observed. As results, the markedly effective rate was 36.67% (11/30) and the total efficiency rate was 93.33% (28/30) in combined treatment group, while they were 10% (3/30) and 56.67% (17/30) in control group. There was significant difference between 2 groups ( χ² = 13.195, P = 0.004). Besides, the neurological function of patients in 2 groups elevated to different degrees at each time point after treatment (P = 0.020). There was no significant difference in the incidence rate of adverse reactions between 2 groups (P = 0.572). The results indicated that the curative effect of butylphthalide sodium chloride injection combined with urokinase in the treatment of acute ischemic stroke is better than that of urokinase.

Key words: Stroke, Propiophenones, Urinary plasminogen activator