摘要： 目的 评价胸椎旁神经阻滞术联合臭氧治疗带状疱疹后遗神经痛临床疗效。方法 共85 例带状疱疹后遗神经痛患者随机接受基础口服药物+ 维生素B12 肌内注射+ 皮损区局部阻滞（A 组），或基础口服药物+ 复方三维B 肌内注射+ 皮损区局部神经阻滞（B 组），或基础口服药物+ 复方三维B 肌内注射+ 胸椎旁神经阻滞+ 皮损区局部神经阻滞（C 组），或基础口服药物+ 复方三维B 肌内注射+ 胸椎旁神经阻滞及臭氧注射+ 皮损区局部神经阻滞（D 组）。分别于治疗前和治疗4 周后进行视觉模拟评分（VAS）、睡眠质量评分（QS）、抑郁自评量表（SDS）评分和血清C-反应蛋白（CRP）检测，综合评价治疗效果。结果 经治疗后，不同处理组患者VAS、QS 和SDS 评分均低于治疗前（P < 0.05）；A、B 和C 组患者治疗前后血清C-反应蛋白水平无明显变化（均P > 0.05）；D 组患者治疗后血清C-反应蛋白水平低于治疗前（P < 0.05）。结论 胸椎旁神经阻滞术联合臭氧是治疗带状疱疹后遗神经痛快捷而有效的方法。
关键词:
神经痛, 带状疱疹后,
神经传导阻滞,
臭氧,
神经心理学测验,
C 反应蛋白质
Abstract: Objective To analyze the clinical efficacy of thoracic paravertebral nerve block with ozone in the treatment of postherpetic neuralgia. Methods Eighty-five patients suffered postherpetic neuralgia were divided into 4 groups: Group A (oral drugs + intramuscular injection of vitamin B12 + local nerve block of lesion area), Group B (oral drugs + intramuscular injection of compound trivitamin B + local nerve block of lesion area), Group C (oral drugs + intramuscular injection of compound trivitamin B + thoracic paravertebral nerve block + local nerve block of lesion area), Group D (oral drugs + intramuscular injection of compound trivitamin B + thoracic paravertebral nerve block with ozone + local nerve block of lesion area). Treatment outcomes were evaluated by Visual Analogue Scale (VAS), Quality of Sleep (QS), Self-Rating Depression Scale (SDS) and C-reactive protein (CRP) before treatment and 4 weeks after treatment. Results After treatment, VAS, QS and SDS scores of 4 groups were lower than that before treatment, and the differences were statistically significant (P < 0.05, for all). There were no significant changes in the level of CRP of group A, B, C before and after treatment (P > 0.05, for all), while a significant change in CRP was observed in patients of group D between before and after treatment (P < 0.05). The improvement of VAS, QS and SDS scores of group D was significantly better than other 3 groups (P < 0.05, for all). Conclusion Thoracic paravertebral nerve block combined with ozone is a quick and effective method for postherpetic neuralgia patients.
Key words:
Neuralgia, postherpetic,
Nerve block,
Ozone,
Neuropsychological tests,
C-reactive protein
郭向飞, 刘亚光, 霍岩松, 吴宪宏, 马骏. 胸椎旁神经阻滞术联合臭氧治疗带状疱疹后遗神经痛临床观察[J]. 中国现代神经疾病杂志, 2013, 13(10): 863-867.
GUO Xiang-fei, LIU Ya-guang, HUO Yan-song, WU Xian-hong, MA Jun. Clinical observation on thoracic paravertebral nerve block with ozone treatment in patients with postherpetic neuralgia[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2013, 13(10): 863-867.