Basic & Clinical Medicine ›› 2010, Vol. 30 ›› Issue (4): 437-441.

• 短篇综述 • Previous Articles    

Research about the relationship between γH2AX, ATM and DNA damage by endogenous oxidants

Jin ZHAO, Zhong GUO, Jian-xiu MA   

  1. Medical College of Northwest University for Minorities Medical College of Northwest University for Minorities
  • Received:2009-06-08 Revised:2009-08-24 Online:2010-04-05 Published:2010-04-05
  • Contact: Jin ZHAO,

Abstract: This review describes the observations that constitutive ATM activation (CAA) and H2AX phosphorylation (CHP) take place caused by endogenous oxidants in normal cells as well in tumor cell lines. This review also presents the findings on differences in CAA and CHP on the effects of several agents and growth conditions.

Key words: endogenous oxidants, γH2AX, ATM

CLC Number: