Abstract: In this article we review the relation between P2 purinoceptor subtypes and coronary heart disease (CHD). P2Y1、P2Y2、P2Y11 and P2X7 receptors relate to inflammatory reaction in atherosclerosis plaque. P2X3 receptor plays an important role in anginal nocuity response. P2X4 receptor involve in vascular remodeling and enhancement of myocardial contractility in non-infarct zone. P2Y2 and P2Y6 receptors involve in restenosis. A polymorphism in P2Y11 receptors adds the risk of myocardial infarction. P2Y1、P2Y12 and P2X1 receptors participate to thrombotic formation. The specific agonist and antagonist of P2 purinoceptor subtypes could be potential targets for new drugs of CHD.