Abstract: Objective To approach the prophylactic function of absorbable gelatin sponge and bioprotein glue in prevention of epidural and nerve root scar adhesions after laminectomy. Methods We excised the L6 vertebral plates of 36 adult New Zealand male rabbits, to make vertebral plate excision model. Probe the nerve root. Then divided them into 3 groups according to different materials: gelatin sponge and bioproten glue (group A ), gelatin sponge ( group B ) and saline solution ( group C ). The morphological changes of the scars were observed grossly and histologically on 2 and 8 weeks after operation, and we also measured the orbit of the nerve root. Results gelatin sponge combining with bioprotein glue can reduce adhesions obviously（P＜0.05）. Conclusions gelatin sponge combining with bioprotein glue can lessen spinal dural mater and nerve root scar adhesions with surrounding tissue.

Key words: Laminectomy, gelatin sponge, bioprotein glue, scar adhesions, Prevention