Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (4): 685-689.doi: 10.16352/j.issn.1001-6325.2023.04.0685

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Research progress on the mechanism of perivascular adipose tissue inflammation promoting atherosclerosis

DU Fenghe1,2, LIU Bao1*   

  1. 1. Department of Vascular Surgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730;
    2. 4+4 Medical Doctor Program, PUMC, Beijing 100730,China
  • Received:2022-12-08 Revised:2023-02-16 Online:2023-04-05 Published:2023-04-03
  • Contact: *

Abstract: Atherosclerosis is harmful to human health. Under pathological conditions including hypertension and hyperlipidemia, increased levels of pro-inflammatory immunocytes in perivascular adipose tissue (PVAT), “whitening” of brown adipose tissue, and oxidative stress could promote the development of PVAT inflammation. PVAT inflammation could induce various crucial stages of atherosclerosis by disturbing secretion of inflammatory and anti-inflammatory adipokines, inhibiting PVAT cell autophagy, and activating angiogenesis in arterial adventitia, thereby promoting the onset and progression of atherosclerosis.

Key words: atherosclerosis, perivascular adipose tissue, cardiovascular disease, basic research, clinical application

CLC Number: