Progress on the role of NLRP3 inflammasome in hyperuricemic nephropathy

doi:10.16352/j.issn.1001-6325.2023.02.322

Abstract

Abstract: Hyperuricemic nephropathy (HN) is a common clinical complication of hyperuricemia, leading to hyperuricemia-associated renal abnormalities. The present review sheds light on the mechanistic aspects pertaining to HN, emphasizing the role of nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in the occurrence and development of HN.This review recommends pharmacological inhibition of NLRP3 infammasome as a therapeutic strategy of HN treatment.

Key words: hyperuricemic nephropathy, hyperuricemia, NLRP3 inflammasome, inhibitor

CLC Number:

R589.7

DAI Zhixin, WANG Yumin. Progress on the role of NLRP3 inflammasome in hyperuricemic nephropathy[J]. Basic & Clinical Medicine, 2023, 43(2): 322-326.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2023.02.322

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2023/V43/I2/322

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