Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (1): 178-182.doi: 10.16352/j.issn.1001-6325.2023.01.0178

• Mini Reviews • Previous Articles     Next Articles

Research progress of pathogenesis and treatment of microorganism-related tumors

SUN Hui, CHEN Siyu*   

  1. Department of Oncology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Received:2021-08-26 Revised:2022-01-28 Published:2022-12-27
  • Contact: *

Abstract: Tumor is a disease with multi-factor participation and multi-stage onset, among which the biological carcinogenic factors are mainly carcinogenic viruses, bacteria and parasites, and the common ones include hepatitis B virus(HPV) and hepatocellular carcinoma, Epstein-Barr virus(EBV) and nasopharyngeal carcinoma, human papilloma virus(HPV) and cervical cancer, Helicobacter pylori and MALT lymphoma,gastric cancer etc.The occurrence and development of certain tumors are closely related to microorganisms, which can play a role in carcinogenesis and cancer promotion through the following mechanisms:producing toxic substances, inducing toxic effects,inducing inflammation, affecting immune response, etc. This review briefly summarizes the carcinogenic and cancer-promoting mechanisms of microorganisms, and looks forward to the new ideas of using microorganisms as biomarkers for early tumor screening and developing drugs by targeting microorganisms.

Key words: microorganism, tumor, pathogenesis, early screening, treatment

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