Progress of immune checkpoint inhibitors for the treatment of myelodysplastic syndrome

Abstract

Abstract: Immune checkpoint inhibitor(ICI) is a potential treatment for MDS by inhibiting the escape of tumor cells and enhancing immune responses. This article reviewed the efficacy and adverse events of clinical trials focusing on PD-1/PD-L1 and CTLA-4 inhibitors on MDS patients. Although the efficacy of single-agent ICI therapy was limited, it may have a synergistic effect with hypomethylation agent (HMA), which could be a choice for patients who fail to respond to HMA treatment. Immune-related adverse events(irAE) were observed, but most can be reversed by steroids.

Key words: immune checkpoint inhibitor, myelodysplastic syndrome, efficacy, safety

CLC Number:

R551

ZHANG Ruo-xi, HAN Bing. Progress of immune checkpoint inhibitors for the treatment of myelodysplastic syndrome[J]. Basic & Clinical Medicine, 2021, 41(8): 1210-1215.

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