Research progress on the role of STAT in the pathogenesis of dermatosis

Abstract

Abstract: Signal transducer and activator of transcription (STAT) proteins with transcriptional activity, which are involved in the pathogenesis and formation of skin lesions of atopic dermatitis, psoriasis, skin tumors and other dermatosis, and are related to the severity of dermatosis. Different STAT has different pathways in dermatosis. STAT regulate cell signal transduction, affect the expression of downstream factors, and exert biological effects. Further study of STAT expression level and targeted genes to explore the relationship between STAT and dermatosis will help to find potential therapeutic targets for dermatosis.

Key words: signal transducer and activator of transcription(STAT), dermatosis, pathway

CLC Number:

R751

ZHOU Qiong-yan, LIN Wei, XU Su-ling, ZHAO Ke-yu. Research progress on the role of STAT in the pathogenesis of dermatosis[J]. Basic & Clinical Medicine, 2021, 41(8): 1205-1209.

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