Abstract: Hematopoietic stem cells (HSCs) senescence is an important reason of hematopoietical and immunological function senescence. It also is play a key role during aging-related diseases development. Under certain conditions, the activation of classical Wnt3a/β-catenin is in favour of maintains polarity and young states of HSCs, self-renewing, proliferation and differentiation potency. Switching to the non-classical Wnt5a pathway, further activation of Cdc42 protein and others can promote HSCs ageing, and indirectly inhibits Wnt3a/beta-catenin pathway. The intervention of two Wnt signaling pathways switching and mechanism, not only can illustrate the mechanism of HSCs aging, but also clear how to slow down ageing. This could provide a new strategy on the solution of age-related diseases and keeping a young state.

Key words: hematopoietic stem cells, senescence, Wnt3a, Wnt5a