Abstract: Necroptosis, it is activated by the formation of necrosome, is a way of programmed cell death that independent of the activation of caspase. Necroptosis is regulated by many factors, for example, RIPK1 can initiate necroptosis, but also inhibit necroptosis; caspase-8 is the key negative regulation factor of necroptosis; CHIP is a new regulation protein of necroptosis. Triggering necroptosis is a promising strategy to overcome apoptosis resistance in cancer.

Key words: necroptosis, RIPK, Caspase8, CHIP, tumor