Basic & Clinical Medicine ›› 2017, Vol. 37 ›› Issue (3): 405-409.

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Research progress on mechanism of autophagy in intestinal mucosal barrier function


  • Received:2016-03-14 Revised:2016-06-03 Online:2017-03-05 Published:2017-02-23

Abstract: Autophagy is a biological process which cells maintain homeostasis through degradation of cytoplasmic macromolecules and damaged organelles by membrane vesicle structure. Autophagy plays a critical role in maintaining survival of intestinal epithelial cells during intestinal mucosal barrier dysfunction. A negative regulator of autophagy can lead to intestinal inflammation and tumorigenesis.

Key words: Autophagy, Intestinal mucosal barrier, PI3K/Akt/mTOR signaling pathway, MicroRNA, Wnt/β-catenin signaling pathway

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