Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (8): 1154-1158.
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Abstract: Melatonin is a hormone secreted by the pineal gland, and regulates many physiological conditions including sleep. Melatonin specifically binds to melatonin receptors, regulating central and peripheral functions. The melatonin receptor-mediated signaling pathways in pancreatic β cell affect pancreatic insulin secretion and the function of pancreatic β cell. The activation of melatonin receptors increases the arylalkylamine-N-acetyltransferase activity, which promotes secretion of melatonin, further inhibiting insulin secretion and elevating blood sugar.
Key words: Key words: melatonin, melatonin receptor, type 2 diabetes, insulin, signaling pathway
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[R34]
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2016/V36/I8/1154