Abstract: The activation of SIRT1 can extend the lifetime of cells, postpone the appearance of senium. SIRT1 also plays an important role in the regulation of the inflammatory reaction. In the process of tissue repair based-mesenchymal stem cells, cell aging and inflammation have an critical influence on the repair ability. Therefore, it is hopeful to change MSCs repair ability by modulating the activity of SIRT1.

Key words: mesenchymal stem cells , SIRT1 , senium , inflammation , bone repair