Basic & Clinical Medicine ›› 2014, Vol. 34 ›› Issue (4): 555-558.

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Progress on Discoidin Domain Receptor1


  • Received:2013-07-08 Revised:2013-09-27 Online:2014-04-05 Published:2014-03-31
  • Contact: De-kui ZHANG

Abstract: Discoidin domain receptor1(DDR1), a novel receptor tyrosine kinase(RTK), specifically binds to and is activated by collagen, consequently triggering a sequence of transmembrane signal transmission functions of cells. Many disease processes such as the development of tumor, inflammatory response and fibrosis have abnormal expressions of DDR1.

Key words: Discoidin domain receptor1, Receptor tyrosine kinases, Tumor, Inflammatory response, Fibrosis

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