Abstract: Problem-based learning (PBL) has been the subject of considerable interest and debate in medical education in recent years. Course-based PBL has been established and applied in the course of 《Stem cell》for graduates which enhances learning by providing a highly motivational environment for acquisition of knowledge. It is satisfied that PBL can help students develop key learning skills and creative ability which make them more confident in their research role.

Key words: problem-based learning, graduate education, stem cell