Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (7): 1134-1138.doi: 10.16352/j.issn.1001-6325.2022.07.1134

• Mini Reviews • Previous Articles     Next Articles

Progress on cholesterol metabolism and non-alcoholic steatohepatitis

LI Xiao-xiao1, SHU Xiang-bing2, ZHANG Li1*   

  1. 1. Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032;
    2. Department of Geratology, Baoshan Branch of Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201999, China
  • Received:2021-01-22 Revised:2021-07-02 Online:2022-07-05 Published:2022-06-29
  • Contact: *

Abstract: Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD). Cholesterol is an essential substance for biological process. Intestinal absorption of dietary cholesterol, as well as circulating lipoprotein exchange, intracellular cholesterol synthesis and metabolism influence hepatic lipid metabolism. It is indicated that the dysfunction of organelles and the secretion of inflammatory cytokines contributed to the activation of cholesterol-loaded macrophage. Besides, cholesterol and bile acid metabolism can also trigger to the development and progression of NASH.

Key words: cholesterol, non-alcoholic steatohepatitis, macrophage, inflammation, bile acid

CLC Number: