Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (1): 168-172.

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Research progress on biomarkers for embryonic development

  

  • Received:2021-02-03 Revised:2021-05-31 Online:2022-01-05 Published:2022-01-05
  • Contact: song shuwang E-mail:wshsong@sina.com

Abstract: Screening high-quality gametes and high developmental potential embryos is focus of assisted reproductive technology. In recent years, studies have found that the embryo culture medium contains proteins secreted by the embryo, free DNA fragments, cytokines and so on, and the nutrients needed for embryo development are obtained from the culture medium. Through Using non-invasive methods, for example embryo metabonomics, proteomics, to analyzed the composition of the embryo culture medium. These biomarkers are helpful for rapid and accurate screening of high-quality embryos with the most developmental potential. This paper summarizes the effects of amino acids, carbohydrates, cytokines and proteins on embryonic development.

Key words: Key words: embryo, culture medium, biomarker, amino acid, cytokine