Research progress on the role of ADAM17 in the pathogenesis of atherosclerosis

Abstract

Abstract: Atherosclerosis is a kind of chronic inflammatory disease involving imbalance of lipid metabolism and immune disorders. The disintegrin metalloprotease 17(ADAM17) is a classic membrane protein shedding enzyme, which promotes atherosclerosis by participating in the process of inflammatory response, angiogenesis and plaque instability. In a few cases, ADAM17 also exhibits anti-atherosclerotic effects. Therefore, paying attention to the mechanism of ADAM17 in atherosclerosis will help to provide new insights into the diagnosis and treatment of atherosclerosis.

Key words: ADAM17, atherosclerosis, inflammation

CLC Number:

R543.5

TANG Bai-yi, WEN Juan, TANG Xiao-hong. Research progress on the role of ADAM17 in the pathogenesis of atherosclerosis[J]. Basic & Clinical Medicine, 2021, 41(5): 744-748.

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