Hydrogen sulfide attenuates diabetic cardiomyopathy by inhibiting oxidative stress

Abstract

Abstract: Although there are a variety of pathological mechanisms attributed to diabetic cardiomyopathy (DCM), oxidative stress is one of the most important causes of DCM. Understanding the occurrence and development of oxidative stress in DCM is very important for the new targeted therapy of DCM. In addition, hydrogen sulfide (H₂S) plays an important role in the treatment of various cardiovascular diseases. In particular, H₂S can reduce DCM by inhibiting oxidative stress through various pathways.

Key words: hydrogen sulfide (H₂S), reactive oxygen species, diabetic cardiomyopathy, protease pathway, non-protease pathway

CLC Number:

R310.4430

JIAO Li-jie, WEI Ya-xin, LI Hong-zhu. Hydrogen sulfide attenuates diabetic cardiomyopathy by inhibiting oxidative stress[J]. Basic & Clinical Medicine, 2021, 41(5): 739-743.

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