Research progress of spinophilin in nervous system diseases

Abstract

Abstract: Spinophilin (SPN) was first isolated from the dendritic spines of neurons as a binding protein of protein phosphatase PP1, it is also known as PPP1R9B. SPN can not only bind to PP1, but also interacts with more than 30 proteins, including cytoskeleton proteins and adhesion molecules. SPN participates in biological processes such as synaptic plasticity, neuronal migration, intracellular signal transduction, and plays an important role in the development of neurodegenerative diseases, psychiatric disorders and neuronal tumors. Therefore, understanding the role and mechanism of SPN in the physiological and pathological processes may support is helpful to advance the basic research and clinical transformation.

Key words: spinophilin, Parkinson's disease, depression, glioma

CLC Number:

R651

XING Jing-song, KE Tian-tian, ZHANG Lin, LIANG Dong, ZHANG Tong, GAO Shang-feng. Research progress of spinophilin in nervous system diseases[J]. Basic & Clinical Medicine, 2021, 41(10): 1507-1509.

References

[1]Allen PB, Ouimet CC, Greengard P. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines[J]. Proc Natl Acad Sci U S A, 1997,94:9956-9961.
[2]Salek AB, Edler MC, McBride JP, et al. Spinophilin regulates phosphorylation and interactions of the GluN2B subunit of the N-methyl-d-aspartate receptor[J]. J Neurochem,2019,151:185-203.
[3]Sarrouilhe D, di Tommaso A, Métayé T, et al. Spinophilin: from partners to functions[J]. Biochimie, 2006,88:1099-1113.
[4]Ouimet CC, Katona I, Allen P, et al. Cellular and subcellular distribution of spinophilin, a PP1 regulatory protein that bundles F-actin in dendritic spines[J]. J Comp Neurol, 2004,479:374-388.
[5]Horling K, Schlegel G, Schulz S, et al. Hippocampal synaptic connectivity in phenylketonuria[J]. Hum Mol Genet,2015,24:1007-1018.
[6]Dunn HA, Ferguson SS. PDZ protein regulation of G protein-coupled receptor trafficking and signaling pathways[J]. Mol Pharmacol, 2015,88:624-639.
[7]Brocos-Mosquera I, Nuñez Del Moral A, Morentin B, et al. Characterisation of spinophilin immunoreactivity in postmortem human brain homogenates[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2018,81:236-242.
[8]Hiday AC, Edler MC, Salek AB, et al. Mechanisms and consequences of dopamine depletion-induced attenuation of the spinophilin/neurofilament medium interaction[J]. Neural Plast, 2017,2017:4153076. doi:10.1155/2017/4153076.
[9]Verdugo-Sivianes EM, Navas L, Molina-Pinelo S, et al. Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer[J]. Oncotarget, 2017,8:105196-105210.
[10]Ferrer I, Blanco-Aparicio C, Peregrina S, et al. Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation[J]. Cell Cycle, 2011,10:2751-2762.
[11]Palavicini JP, Wang H, Bianchi E, et al. RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes[J].Cell Death Dis, 2013,4:e667. doi:10.1038/cddis.2013.183.
[12]Taniguchi K, Yamamoto F, Arai T, et al. Tyrosol reduces amyloid-β oigomer neurotoxicity and alleviates synaptic, oxidative, and cognitive disturbances in Alzheimer's disease model mice[J]. J Alzheimers Dis, 2019,70:937-952.
[13]Mi Z, Abrahamson EE, Ryu AY, et al. Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer's disease[J]. Neurobiol Aging, 2017,55:159-166.
[14]Akram A, Christoffel D, Rocher AB, et al. Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease[J]. Neurobiol Aging, 2008,29:1296-1307.
[15]Gao S, Zhang T, Jin L, et al. CAPON is a critical protein in synaptic molecular networks in the prefrontal cortex of mood disorder patients and contributes to depression-like behavior in a mouse model[J]. Cereb Cortex, 2019,29:3752-3765.
[16]Edler MC, Salek AB, Watkins DS, et al. Mechanisms regulating the association of protein phosphatase 1 with Spinophilin and Neurabin[J]. ACS Chem Neurosci, 2018,9:2701-2712.
[17]Wesseling P, Capper D. WHO 2016 Classification of gliomas[J]. Neuropathol Appl Neurobiol, 2018,44:139-150.
[18]Cheerathodi M, Avci NG, Guerrero PA, et al. The cytoskeletal adapter protein Spinophilin regulates invado-podia dynamics and tumor cell invasion in glioblastoma[J]. Mol Cancer Res, 2016,14:1277-1287.