Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy

Abstract

Abstract: Diabetic nephropathy is a common chronic microvascular complication in diabetic patients. Mesangial cell is the main cell type in glomeruli. High glucose stimulation can promote mesangial cell proliferation by reducing endogenous hydrogen sulfide concentration, activating transforming growth factor-β superfamily and influencing long non-coding RNA level. Abnormal activation of mesangial cells plays an important role in the pathogenesis of diabetic glomerulosclerosis.

Key words: diabetic nephropathy, glomerulosclerosis, high glucose, mesangial cell

CLC Number:

R587.1

SUN Feng-qi, WU Ren, CHANG Gui-quan, LI Hong-zhu. Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy[J]. Basic & Clinical Medicine, 2021, 41(10): 1510-1513.

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