Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (1): 103-107.

• Mini Reviews • Previous Articles     Next Articles

Research progress of bile acid metabolism in complications of liver cirrhosis

ZHANG Xue-mei1, LI Jun-feng1*, MAO Xiao-rong2*   

  1. 1. the First Clinical Medical College; 2. Department of Infection, the First Hospital, Lanzhou University, Lanzhou 730000, China
  • Received:2019-12-05 Revised:2020-03-26 Online:2021-01-05 Published:2020-12-30
  • Contact: *;

Abstract: Bile acids are synthesized from cholesterol in hepatocytes and play an important role in the absorption, transport and distribution of fat and fat soluble vitamins. They also act as important signal molecules to regulate metabolism and inflammatory response. The accumulation of bile acids in the body and the activation of bile acid related receptors can aggravate or alleviate the complications of liver cirrhosis such as hepatic encephalopathy, portal hypertension and peritonitis.

Key words: bile acid, hepatic encephalopathy, portal hypertension, peritonitis

CLC Number: