[1] 李阳, 张立萍, 罗洋. 哈尔滨市社区老年人衰弱现状及其影响因素调查[J]. 护理研究, 2018, 32: 224-228. [2] Fried LP, Tangen CM. Frailty in older adults: evidence for a phenotype[J]. J Gerontol A Biol Sci Med Sci, 2001, 56: 146-156. [3] Biagi E, Rampelli S, Turroni S, et al. The gut microbiota of centenarians: signatures of longevity in the gut microbiota profile[J]. Mech Ageing Dev, 2017, 165: 180-184. [4] Van Tongeren SP, Slaets JP, Harmsen HJ, et al. Fecal microbiota composition and frailty[J]. Appl Environ Microbiol, 2005, 71: 6438-6442. [5] Zhang L, Liao J, Chen Q, et al. Characterization of the gut microbiota in frail elderly patients[J]. Aging Clin Exp Res, 2019, 26: 1-11. [6] Jackson MA, Jeffery IB, Beaumont M, et al. Signatures of early frailty in the gut microbiota[J]. Genome Med, 2016, 8: 8-18. [7] Theou O, Jayanama K, Fernández-Garrido J, et al. Can a prebiotic formulation reduce frailty levels in older people?[J]. J Frailty Aging, 2019, 8: 48-52. [8] Buigues C, Fernández-Garrido J, Pruimboom L, et al. Effect of a prebiotic formulation on frailty syndrome:a randomized, double-blind clinical trial[J]. Int J Mol Sci, 2016, 17: 932-943. [9] Leng S, Chaves P, Koenig K, et al. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty:a pilot study[J]. J Am Geriatr Soc, 2002, 50: 1268-1271. [10] Thevaranjan N, Puchta A, Schulz C, et al. Age-asso-ciated microbial dysbiosis promotes intestinal permeabi-lity, systemic inflammation, and macrophage dysfunction[J]. Cell Host Microbe, 2017, 21: 455-466. [11] 刘晓蕾, 岳冀蓉, 乔闰娟, 等. 肠道菌群在肌少症发病机制中的作用[J]. 实用老年医学, 2019, 33: 840-843. [12] 李姝敏, 汪晶美, 李晗宇, 等. 老年肌少症患者骨骼肌质量指数与肥胖、骨质疏松及肠道菌群的相关性研究[J]. 中华危重症医学杂志(电子版), 2018, 11: 7-11. [13] Andrea T, Fulvio L, Christian M, et al. Aging gut microbiota at the cross-road between nutrition, physical frailty, and sarcopenia:is there a gut-muscle axis?[J]. Nutrients, 2017, 9: 1303-1322. [14] Virtuoso Júnior JS, Roza LB, Tribess S, et al. Time spent sitting is associated with changes in biomarkers of frailty in hospitalized older adults:a cross sectional study[J]. Front Physiol, 2017, 8: 505-510. [15] 贺莹莹, 王艺蕊, 何辉, 等. 不同体力活动水平对女性肠道菌群的影响[J]. 航天医学与医学工程, 2019, 32: 420-425. [16] 于春霞, 傅力. 肠道菌群-运动干预防治代谢性疾病的新靶点[J]. 中国运动医学杂志, 2017, 36: 443-447. [17] Schretter CE, Vielmetter J, Bartos I, et al. A gut micro-bial factor modulates locomotor behaviour in Drosophil[J]. Nature, 2018, 563: 402-406. [18] Scheperjans F, Aho V, Pereira PAB, et al. Gut microbiota are related to Parkinson's disease and clinical phenotype[J]. Mov Disord, 2015, 30: 350-358. [19] Morita E, Yokohama H, Imai D, et al. Aerobic exercise training with brisk walking increases intestinal Bacteroides in elderly women[J]. Nutrients, 2019, 11: 868-884. [20] Frémont M, Coomans D, Massart S, et al. High-through-put 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients[J]. Anaerobe, 2013, 22: 50-56. [21] Logan AC, Venket Rao A, Irani D. Chronic fatigue syndrome:lactic acid bacteria may be of therapeutic value[J]. Med Hypothesis, 2003, 60: 915-923. [22] Sheedy JR, Wettenhall RE, Scanlon D, et al. Increased D-lactic acid intestinal bacteria in patients with chronic fatigue syndrome[J]. In Vivo, 2009, 23: 621-628. [23] Bajaj JS, Ridlon JM, Hylemon PB, et al. Linkage of gut microbiome with cognition in hepatic encephalopathy[J]. Am J Physiol Gastrointest Liver Physiol, 2012, 302: 168-175. [24] Vogt NM, Kerby RL, Dill-Mcfarland KA, et al. Gut microbiome alterations in Alzheimer's disease[J]. Sci Rep, 2017, 7: 13537.doi:10.1038/s41598-017-13601-Y. [25] Cattaneo A, Cattane N, Galluzzi S, et al. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly[J]. Neurobiol Aging, 2017, 49: 60-68. |