Research progress of tumorigenicity-related proteins

Abstract

Abstract: The occurrence and development of tumors include the tumorigenicity of tumor cells in vivo, the growth of xenograft tumors, angiogenesis, tumor migration, invasion and metastasis. Tumorigenicity-related proteins play an important regulatory role during these processes. Research of tumorigenicity-related proteins is of great significance for identifing new targets for tumor treatment and blocking tumor occurrence and development. We reviewed the effects of tumorigenicity-related proteins on cell tumorigenesis, the consequence of protein interactions on tumor migration and invasion, the effects of tumorigenicity-related proteins on cell migration and invasion in vitro, and their relationship with tumor metastasis. This review provides rich information on the regulatory mechanism of tumorigenicity-related proteins in tumor development.

Key words: tumor cells, tumorigenicity, protein

CLC Number:

AO Hui-juan, SHI Jia-chen, WANG Jia-min, Ayimuguli ABUDUREYIMU, QIAO Zi-lin, YANG Kun. Research progress of tumorigenicity-related proteins[J]. Basic & Clinical Medicine, 2020, 40(12): 1716-1720.

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