Research progress on the diseases caused by abnormal expression of transcription regulator FOXN1

Abstract

Abstract: Since report of FOXN1 deficiency, the function of FOXN1 in thymus and skin has been focused on increasingly. FOXN1 is the critical regulator for the development of thymus epithelial cells which determines the development and maturation of T cells, therefore, FOXN1 is fundamental for thymus development, function, and homeostasis. In the skin, it also plays a pivotal role in keratinocytes and hair follicle cell differentiation, however, the underlying molecular mechanisms are still not fully elucidated.

Key words: Key words: FOXN1, TEC, SCID, related diseases

CLC Number:

R392.9

Xiao He Yin-Hong SONG. Research progress on the diseases caused by abnormal expression of transcription regulator FOXN1[J]. Basic & Clinical Medicine, 2019, 39(2): 264-267.

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Research progress on the diseases caused by abnormal expression of transcription regulator FOXN1

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