Progress of chimeric antigen receptor-modified T cell therapy for osteosarcoma

Basic & Clinical Medicine ›› 2018, Vol. 38 ›› Issue (7): 1012-1015.

Progress of chimeric antigen receptor-modified T cell therapy for osteosarcoma

Chen-Xi TONG¹,Yin-Hong SONG

Received:2017-03-27 Revised:2017-07-14 Online:2018-07-05 Published:2018-06-29
Contact: Yin-Hong SONG E-mail:syh728@126.com

Abstract

Abstract: Osteosarcoma(OS) is one common type of bone malignancy. Conventional treatments improved survival dramatically. However, conventional therapies reveal the limited effects for patients with metastatic disease. Targeting osteosarcoma-associated antigen, chimeric antigen receptor-modified T cell(CAR-T) therapy is promising treatment. Specific CAR-T treatments of osteosarcoma including targeting HER-2, IL-11Rα, ROR1 and GD2 have shown a certain therapeutic effect on osteosarcoma in some basic and clinical studies.

Key words: Key words: chimeric antigen receptor-modified T(CAR-T)cell, osteosarcoma, immunotherapy

CLC Number:

R738
R392.9

Chen-Xi TONG Yin-Hong SONG. Progress of chimeric antigen receptor-modified T cell therapy for osteosarcoma[J]. Basic & Clinical Medicine, 2018, 38(7): 1012-1015.

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Progress of chimeric antigen receptor-modified T cell therapy for osteosarcoma

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