Abstract: Osteosarcoma(OS) is one common type of bone malignancy. Conventional treatments improved survival dramatically. However, conventional therapies reveal the limited effects for patients with metastatic disease. Targeting osteosarcoma-associated antigen, chimeric antigen receptor-modified T cell(CAR-T) therapy is promising treatment. Specific CAR-T treatments of osteosarcoma including targeting HER-2, IL-11Rα, ROR1 and GD2 have shown a certain therapeutic effect on osteosarcoma in some basic and clinical studies.

Key words: Key words: chimeric antigen receptor-modified T(CAR-T)cell, osteosarcoma, immunotherapy