Basic & Clinical Medicine ›› 2017, Vol. 37 ›› Issue (9): 1326-1330.
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Abstract: Exosomal miRNAs, derived from tumor cells or their microenvironment, could promote the proliferation, migration and invasion of tumor cells; and enhance tumor metastasis via regulating information exchange between tumor cells and immune cells or metastatic target organs; and induce tumor resistance to cisplatin and gemcitabine; meanwhile, detecting the exosomal miRNAs in the serum and saliva of cancer patients suggested the potential of application in cancer diagnosis and prognosis assessment.
Key words: tumor, microenvironment, exosome, miRNAs, tumorigenic mechanism.
CLC Number:
R363
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2017/V37/I9/1326