Abstract: Objective The aim of this study was to evaluate the safety and prognosis of ovarian preservation in young women with early-stage endometrial cancer. Methods Women≤45 years of age with stageⅠendometrial cancer recorded from Jan 2005 to Dec 2011 in Peking Union Medical College Hospital were examined. They were further divided into two groups: ovarian preservation group and oophorectomy group. Clinical and pathological recording of these patients were compared. Results A total of 72 women, including 25 patients (34.7%) who had ovarian preservation, were identified. The ovarian preservation group was younger (P=0.007) and had a lower prevalence of lymphadenectomy (P<0.001). While there were no significant difference in stage, tumor grade, the invasion depth of myometrium and adjuvant treatment between two groups (all P>0.05). Of seventy-two cases, five patients relapsed and all survived after a median follow-up time of 89 months (rang: 7-131 months). The Kaplan-Meier curve and the log rank test showed no difference in recurrence-free survival (P=0.194). In Cox model analysis, ovarian preservation had no effect on recurrence-free survival (HR=3.08, 95% CI 0.54-18.44). Conclusions Ovarian preservation in young women with early-stage endometrial cancer is safe and has no negative effect on recurrence-free survival or overall survival.

Key words: endometrial cancer, ovarian preservation, prognosis