Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (4): 520-525.

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The expression and effect of long noncoding RNA Linc00467 in colorectal cancer

Li-na WU1,Xiao-zhong PENG   

  • Received:2015-09-14 Revised:2016-01-14 Online:2016-04-05 Published:2016-03-29

Abstract: Objective To explore the expression and function of lncRNA Linc00467 in colorectal cancer. Methods 67 patients of colorectal cancer were selected and their clinicopathological characteristics were collected. The expression level of Linc00467 in colorectal cancer tissues, adjacent normal tissues, normal colon cells and colon cancer cells were detected by real-time PCR. Results The expression level of Linc00467 in human colorectal cancer tissues and colon cancer cells were significantly high. There is no significant difference between the expression level of Linc00467 and clinicopathological characteristics of colorectal cancer. Linc00467 promoted CRC cell proliferation and migration. Conclusions Linc00467 may serve as a new biomarker in human colorectal cancer.

Key words: Key words:long noncoding RNA, colorectal cancer, Linc00467