Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (1): 116-120.
Previous Articles Next Articles
Received:
Revised:
Online:
Published:
Contact:
Supported by:
Abstract: TFEB could induced by autophagic regulatory factors, such as mTOR and cellular stresses. TFEB could media the translation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PPAR α), peroxisome proliferator-activated receptor γ coactivator 1 α(PGC-1α) and autophagy, lysosomal synthesis related genes, then regulat lipid metabolism and the release inflammatory cytokine. AS a novel Mechanism, TFEB could regulate Lipid metabolism in order to restrain the progression of atherosclerosis and promote to plaque stabilization.
Key words: TFEB , atherosclerosis, autophagy, PPAR α, PGC-1α
0 / / Recommend
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2016/V36/I1/116