Abstract: PRAS40, a substrate of protein kinase B (PKB/ Akt), is a specific binding protein of mTORC1. There are several conservative phosphorylation sites in PRAS40 including Thr246 induced by Akt and Ser183, Ser212 and Ser221 regulated by mTORC1. When phosphorylated, PRAS40 interacts with Raptor or 14-3-3 protein and participates in regulating the activity of Akt and mTORC1. PRAS40 also plays an important role in insulin resistance, neurodegenerative disorders and cancer owing to its function in regulating cell growth and neuroprotective effects. As a result, PRAS40 may be a promising drug target.

Key words: KEY WORDS: PRAS40, phosphorylation, insulin resistance, neurodegenerative disorders, cancer