Abstract: P16 (CDKN2A/MTS1) gene is a cell cycle regulator involved in the inhibition of G1 phase progression and P16 methylation is associated with the progression of gastric cancer. Helicobacter pylori infection is one of the most important risk factors for gastric cancer. H. pylori infection could potently induce methylation of P16 CpG island. The inactivation of P16 by methylation of CpG islands could cause gastric cancer.

Key words: helicobacter pylori, P16 gene, DNA methylation, gastric cancer