Basic & Clinical Medicine ›› 2014, Vol. 34 ›› Issue (11): 1574-1577.

Previous Articles     Next Articles

Research progress in cell metabolism of glucose and lipid regulated by transcription factors via mTOR

  

  • Received:2014-02-17 Revised:2014-04-18 Online:2014-11-05 Published:2014-11-03

Abstract: The mammalian target of rapamycin(mTOR) is an important signal molecule in a variety of physiological mechanisms, including protein synthesis, cell proliferation, cell cycle, energy metabolism, autophagy, etc. It is increasingly apparent that mTOR deregulation occurs in cancer and metabolism disorders. The transcription factors of downstream of mTOR such as HIF1α, c-Myc, FoxO1, SREBPs, PPARγ/PPARα and TFEB play key roles in regulating the metabolism of glucose and lipid.

Key words: mTOR, glucose metabolism, lipid metabolism, transcription factor

CLC Number: