Abstract: Background: The aim of the present study was to assess the association between the human CYP4A11 gene and myocardial infarction (MI), using case-control study with a separate analysis of the gender groups. Methods: 166 MI patients and 158 controls were genotyped for 3 single-nucleotide polymorphisms (SNPs) of the human CYP4A11 gene (rs9332978, rs3890011, rs1126742). The data were assessed via case-control studies. Results: The distribution of SNP2 (rs3890011) genotypes showed significant difference between the MI and control subjects (P＜0.05), the distribution of the recessive model of SNP2 (rs3890011) (GG vs CC+GC) was significantly higher in MI patients than control subjects (P＜0.05). The significance of the recessive model of SNP2 (GG vs CC+GC) between MI patients and control subjects retained after adjustment for covariates, (95%CI: 1.138-2.432, P＜0.01). Conclusions: rs3890011 is a novel polymorphism of CYP4A11 gene that is associated with MI, GG genotype of rs3890011 appears to be genetic markers of MI.

Key words: CYP4A11, single-nucleotide polymorphism, case-control study