Abstract: Helicobacter pylori is a microbial pathogen that causes erosions of gastric epithelial cells, via escaping immune killing in local, which leads to a sustaining infection, and it is associated with various gastric diseases. Autohagy is an evolutionary cell mechanism which not only eliminates intercellular microorganisms, but also has no influence to the survival of cells. Helicobacter pylori invade into gastric epithelial cells and certain immune cells, inducing the occurrence of autophagy, and are cleared off after replicating in the autophagsomes. It is assumed that autophagy might play an important role in Helicobacter pylori infection.