Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (2): 210-213.

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The AU-rich element, an important element of post-transcriptional regulation

  

  • Received:2010-04-07 Revised:2010-05-16 Online:2011-02-05 Published:2011-03-14
  • Contact: Yun XU E-mail:xuyun20042001@yahoo.com.cn

Abstract: The adenine and uridine-rich elements(AREs) are found in the 3 ’ untranslated region(3’-UTR) of certain messenger RNAs(mRNAs). AREs have been shown to decrease the stability of mRNAs in which they reside, they can also increase the stability of some mRNAs. ARE binding proteins (ARE-BPs) and the p38 mitogen-activated protein kinase (MAPK) pathway play important roles in regulating the stability of ARE-mRNAs. And microRNAs(miRNAs) pathway may interact with AREs.

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