Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (2): 134-138.

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The mRNA Expression of Adiponectin receptor 1 and 2 in Human Adrenal Tissues and tumors

  

  1. 1. PUMC Hospita, lCAMS& PUMC
    2.
  • Received:2010-03-02 Revised:2010-08-25 Online:2011-02-05 Published:2011-03-14
  • Contact: ZENG Zheng-pei E-mail:zengzhengpei@yahoo.com.cn

Abstract: Objectives: We compare the mRNA expression of the Adiponectin receptor 1 and Adiponectin receptor 2(Adipo R1/R2) in human adrenal tissues and tumors. METHODS: Total RNA was exracted from 6 normal human adrenal glands, 10 cortisol-secreting tumors, 20 pheochromacytomas; and 14 aldosteronomas. We use RT-PCR to compare the mRNA expression of the Adipo R1/R2 in human adrenal tissues and tumors and analyzed the relationship between Adipo R1/R2 , the GLUAUC and INSAUC of 3hOGTT. RESULTS: The mRNA expressions of AdipoR1/GAPDH and AdipoR2/GAPDH were significantly lower in normal human adrenal cortex than in aldosteronoma and cortisol-secreting tumors(p<0.01). The mRNA expressions of AdipoR1/GAPDH in pheochromacytomas were higher than normal human adrenal medulla(p<0.01). The mRNA expressions of AdipoR2/GAPDH in aldosteronoma were lower than cortisol-secreting tumors(p<0.05), Adipo R1 positively correlated with Adipo R2(r=0.335, p<0.01), Adipo R2 positively correlated with GLUAUC(r=0.633,p<0.001). CONCLUSIONS: Adiponectin was widely expressed in adrenal tissues, the difference may be caused by the plasma adiponectin.

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