Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (2): 134-138.
Previous Articles Next Articles
Received:
Revised:
Online:
Published:
Contact:
Abstract: Objectives: We compare the mRNA expression of the Adiponectin receptor 1 and Adiponectin receptor 2(Adipo R1/R2) in human adrenal tissues and tumors. METHODS: Total RNA was exracted from 6 normal human adrenal glands, 10 cortisol-secreting tumors, 20 pheochromacytomas; and 14 aldosteronomas. We use RT-PCR to compare the mRNA expression of the Adipo R1/R2 in human adrenal tissues and tumors and analyzed the relationship between Adipo R1/R2 , the GLUAUC and INSAUC of 3hOGTT. RESULTS: The mRNA expressions of AdipoR1/GAPDH and AdipoR2/GAPDH were significantly lower in normal human adrenal cortex than in aldosteronoma and cortisol-secreting tumors(p<0.01). The mRNA expressions of AdipoR1/GAPDH in pheochromacytomas were higher than normal human adrenal medulla(p<0.01). The mRNA expressions of AdipoR2/GAPDH in aldosteronoma were lower than cortisol-secreting tumors(p<0.05), Adipo R1 positively correlated with Adipo R2(r=0.335, p<0.01), Adipo R2 positively correlated with GLUAUC(r=0.633,p<0.001). CONCLUSIONS: Adiponectin was widely expressed in adrenal tissues, the difference may be caused by the plasma adiponectin.
CLC Number:
0 / / Recommend
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2011/V31/I2/134