Abstract: MicroRNAs (miRNAs) are a class of 20-24 nt non-coding RNAs that regulate gene expression primarily through posttranscriptional repression or mRNA degradation in a sequence-specific manner. It was reported that miRNAs have an important role on the regulation of new blood vessels. The thesis summarized miRNAs associated with therapeutic angiogenesis and reviewed latest studies of mechanism and clinic application of this novel therapy.