Abstract: Cachexia is the result of interaction between host and tumor，whose main manifestation are weight loss in short-term, malnutrition and so on.The inflammatory cytokines secreted by host and cachexia specific factor secreted by tumor are the main cause of cachexia . High-energy diet alone can not improve the condition. Recently, immunonutrition、traditional medicine and drug intervention can alleviate the weight loss and prolong survival in cachexia and thus has a promising prospect.