Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (1): 1-5.

• 研究论文 •     Next Articles

Effect of repetitive transcranial agnetic stimulation on the brain plasticity of rats after middle cerebral artery occlusion reperfusion injury

XU Tao 1,XING Yan 2,CUI Li-ying 1   

  1. 1. PUMC Hospital, CAMS & PUMC2.
  • Received:2008-08-06 Revised:2010-05-05 Online:2011-01-05 Published:2011-01-05
  • Contact: CUI Li-ying

Abstract: Objective To explore the effect of rTMS on the plasticity of the brain after ischemic injury. Methods SD rat MCAO-reperfusion model was established and then were divided into four groups. Different rTMS were applied within 7 days after the reperfusion. The neurological impairment evaluation score of rats were recorded during this period. Immunohistochemistry and Western blot techniques were used to detect GAP-43 and SYN protein expressions. Results rTMS could improve rehabilitation of neurofunction. rTMS could increase the protein expression levels of GAP-43 and SYN. The therapeutic effect of high frequency and high intensity of rTMS was statistically better than other groups (P<0.05). Conclusion The application of rTMS continuously could enhance the plasticity of the brain and improve neurofunction.