Abstract: Objective To investigate the effect of Tectoridin on the lipoprotein of the rat with hyperlipidemia and it?s mechanism. Method 48 healthy male Wistar rats were devided randomly into four groups, high fat diet model group; high doge Tectoridin group; low doge Tectoridin group and Atorvastin group. Each rat was given drugs with intragastric administration after fed with high fat forage for 2 weeks. All the rats blood lipid was mensurated after 12 weeks. LDL-R and it?s mRNA expression in rats? liver were determined by immunohistochemical and RT-PCR method. Result Tectoridin markedly reduced the rat serum lipid and raised the LDL-R and it?s mRNA expression in rats? liver, especially to total cholesterol and low density lipoprotein-cholesterol. Conclusion Tectoridin had significant effect on reducing the rat?s serum lipid perhaps because of increasing the expression of LDL-R in liver of the rat with hyperlipidemia.

Key words: Tectoridin, haperlipidemia, cholesterol, Receptor of low density lipoprotein-cholesterol