Basic & Clinical Medicine ›› 2010, Vol. 30 ›› Issue (9): 912-917.

• 研究论文 • Previous Articles     Next Articles

Cardiac Repolarization Analysis Based on T-wave Morphology in an Adult Population from Heilongjiang Province

Xiao-lin YANG, Jing ZHANG, Shao-mei HAN, Zheng-guo ZHANG, Guang-jin ZHU   

  1. Institute of Basic Medical Sciences, CAMS & School of Basic Medicine, PUMC Institute of Basic Medical Sciences, CAMS & School of Basic Medicine, PUMC IBMS, CAMS, School of Basic Medicine of PUMC
  • Received:2010-07-19 Revised:2010-07-22 Online:2010-09-05 Published:2010-09-05
  • Contact: Guang-jin ZHU

Abstract: Objective To analyze the characteristics of ventricular repolarization variables based on T-wave morphology and to determine their relationships with age, sex, blood pressure, heart rate and cardiac hypertrophy in an adult population from Heilongjiang province. Methods A total of 2514 subjects (range 35-81years; 43% men) were included. Bazett corrected QT interval (QTcB), Fridericia corrected QT interval (QTcF) and four T-wave morphology parameters total cosine R-to-T(TCRT), T-wave morphology dispersion(TMD), relative T-wave residuum(rTWR) and principle component T-wave analysis ratio(PCA ratio) were used to evaluate the ventricular repolarization. Multivariate regression was used to test for the dependence of T-wave morphology variables with the subject age, sex, systolic blood pressure and Sokolow index. Result All ventricular repolarization variables had significant sex different (P<0.05). All parameters but TCRT were higher in the high blood pressure group (P<0.05). Age, sex and systolic pressure had independent effect on ventricular repolarization variables. Sokolow index only had effect on T-wave morphology variables. Conclusion T-wave morphology variables are quantified marker of ventricular repolarization heterogeneity, which was influenced by age, sex, blood pressure and myocardial hypertrophy.

Key words: electrocardiography, ventricular repolarization, T-wave morphology analysis